BPIFB3:BPI fold-containing family B member 3

Gene Name
BPI fold-containing family B member 3
Protein ID
P59826
Chromosome ID
20
HPP Status
2
Protein Name
BPI fold-containing family B member 3
Synonyms

BPIFBP3

chromosome 20 open reading frame 185

BPI fold containing family B, member 3

Long palate, lung and nasal epithelium carcinoma-associated protein 3

LPLUNC3

Ligand-binding protein RYA3

C20orf185

long palate, lung and nasal epithelium carcinoma-associated protein 3

BPI fold-containing family B member 3

dJ726C3.4

RYA3

ligand-binding protein RYA3

long palate, lung and nasal epithelium carcinoma associated 3


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BPIFB3 ]
Chromosomal Position
20q11.21 | Start:33055424 End:33055424
Sequence
P59826.fasta
Description

UniProtKB Summary for BPIFB3
Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BPIFB3 ]
External IDs
Hgnc ID: 16178 EntrezGene ID: 359710 Ensembl ID: ENSG00000186190
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BPIFB3 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20237496Observational study of gene-disease association. (HuGE Navigator)2010-04-07
25491355Overexpression of BPIFB3 inhibits coxsackievirus B replication, dramatically alters the morphology of LC3B-positive vesicles, and suppresses autophagy in response to rapamycin.2015-06-27
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianBPIB3_HUMANBPIB3_MOUSE47645778.9996.0196019475164722.00E-162570
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
BPIB3_HUMANIPR001124GO:0008289DomainLipid-binding serum glycoprotein, C-terminalMolecular Functionlipid binding
BPIB3_HUMANIPR017942GO:0008289DomainLipid-binding serum glycoprotein, N-terminalMolecular Functionlipid binding
BPIB3_HUMANIPR017943GO:0008289DomainBactericidal permeability-increasing protein, alpha/beta domainMolecular Functionlipid binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/P59826_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/P59826_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P59826_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB