CST9:Cystatin-9

Gene Name
Cystatin-9
Protein ID
Q5W186
Chromosome ID
20
HPP Status
2
Protein Name
Cystatin-9
Synonyms

Cystatin-like molecule

cystatin 9 (testatin)

CTES7A

CLM

cystatin-like molecule

cystatin-9


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CST9 ]
Chromosomal Position
20p11.21 | Start:23602410 End:23602410
Sequence
Q5W186.fasta
Description

Entrez Gene Summary for CST9
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted protein that may play a role in hematopoietic differentiation or inflammation. (provided by RefSeq, Jul 2008)

UniProtKB Summary for CST9
Function: May play a role in hematopoietic differentiation or inflammation

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CST9 ]
External IDs
Hgnc ID: 13261 EntrezGene ID: 128822 Ensembl ID: ENSG00000173335
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CST9 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12535658Data report the cloning of a novel human cystatin-like molecule (CLM) from human bone marrow stromal cell (BMSC) cDNA library.2010-01-21
23922243The current report is the first to show the immunomodulatory and antimicrobial functions of rCST9 against Francisella tularensis.2013-12-28
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CST9_HUMANIPR000010GO:0004869DomainProteinase inhibitor I25, cystatinMolecular Functioncysteine-type endopeptidase inhibitor activity
CST9_HUMANIPR027214GO:0004869FamilyCystatinMolecular Functioncysteine-type endopeptidase inhibitor activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q5W186_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q5W186_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB