DEFB118:Beta-defensin 118

Gene Name
Beta-defensin 118
Protein ID
Q96PH6
Chromosome ID
20
HPP Status
1
Protein Name
Beta-defensin 118
Synonyms

epididymus specific clone 42

C20orf63

defensin, beta 18

DEFB-18

Defensin, beta 118

epididymal secretory protein 13.6

defensin, beta 118

Epididymal secretory protein 13.6

DEFB18

Beta-defensin 18

ESC42

ESP13.6

chromosome 20 open reading frame 63

beta-defensin 118


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEFB118 ]
Chromosomal Position
20q11.21 | Start:31368618 End:31368618
Sequence
Q96PH6.fasta
Description

Entrez Gene Summary for DEFB118
This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. (provided by RefSeq, Dec 2010)

UniProtKB Summary for DEFB118
Function: Has antibacterial activity (Potential)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEFB118 ]
External IDs
Hgnc ID: 16196 EntrezGene ID: 117285 Ensembl ID: ENSG00000131068
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEFB118 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15033915DEFB118 may contribute to epididymal innate immunity and provide antimicrobial activity against microorganisms attacking sperm in the male and female reproductive tracts.2014-11-04
19423540Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20237496Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20406964Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20438785Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2010-06-30
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianDB118_HUMANDB118_PANTR12312397.5610030112311231.00E-60228
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q96PH6_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q96PH6_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q96PH6_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB