GBGT1:Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

Gene Name
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Protein ID
Q8N5D6
Chromosome ID
9
HPP Status
2
Protein Name
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Synonyms

"Forssman synthetase"

UNQ2513

Forssman glycolipid synthetase (FS)

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

forssman glycolipid synthase-like protein

A3GALNT

Forssman glycolipid synthase-like protein

FS

"Forssman glycolipid synthetase (FS)"

EC 2.4.1.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GBGT1 ]
Chromosomal Position
9q34.2 | Start:133152948 End:133152948
Sequence
Q8N5D6.fasta
Description

Entrez Gene Summary for GBGT1
This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2013)

UniProtKB Summary for GBGT1
Function: Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GBGT1 ]
External IDs
Hgnc ID: 20460 EntrezGene ID: 26301 Ensembl ID: ENSG00000148288
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GBGT1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20800603Observational study of gene-disease association. (HuGE Navigator)2010-12-05
23255552The Fs synthase gene, GBGT1, in A(pae) individuals encoded an arginine to glutamine change at residue 296.2013-04-27
25294702GBGT1 expression is epigenetically silenced through promoter hypermethylation in ovarian cancer.2015-02-28
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
GBGT1_HUMANIPR005076GO:0005975FamilyGlycosyl transferase, family 6Biological Processcarbohydrate metabolic process
GBGT1_HUMANIPR005076GO:0016020FamilyGlycosyl transferase, family 6Cellular Componentmembrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa00603KEGG PATHWAYGlycosphingolipid biosynthesis - globo series
hsa01100KEGG PATHWAYMetabolic pathways
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-2 of 2 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
MHRRRLALGLGFCLLAGTSLSVLWred-7.351ENSP00000361113Proteotypic
MHRRRLALGLGFCLLAGTSLSVLWred-7.351ENSP00000361113Proteotypic
Evidence File
/mnt/mpp/ms_data/Q8N5D6_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8N5D6_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8N5D6_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB