DEC1:Deleted in esophageal cancer 1

Gene Name Deleted in esophageal cancer 1	Protein ID Q9P2X7	Chromosome ID 9	HPP Status 2
Protein Name Deleted in esophageal cancer 1		Synonyms candidate tumor suppressor CTS9 CTS9 Candidate tumor suppressor CTS9 deleted in esophageal cancer 1 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEC1 ]
Chromosomal Position 9q33.1 \| Start:115141818 End:115141818		Sequence Q9P2X7.fasta
Description Entrez Gene Summary for DEC1 The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. (provided by RefSeq, Jul 2008) UniProtKB Summary for DEC1 Function: Candidate tumor suppressor [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEC1 ]
External IDs Hgnc ID: 23658 EntrezGene ID: 50514 Ensembl ID: ENSG00000173077 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEC1 ]
Reference Source http://www.nextprot.org

Gene Reference Into Function (GeneRIF)

PubMed ID	GeneRIF Text	Last Update
15580306	DEC1 is a candidate tumor suppressor gene that may be involved in esophageal squamous cell carcinoma development	2010-01-21
17943723	Decreased expression of candidate DEC1 is associated with esophageal carcinoma	2010-01-21
19339270	Observational study of gene-disease association. (HuGE Navigator)	2009-04-22
19624270	The hypoxia-regulated transcription factor DEC1 and its expression in gastric cancer are reported.	2010-01-21
20379614	Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)	2010-06-30
20935061	DEC1 promoter -249 T>C (rs2012775) polymorphism is functional, modulating susceptibility to squamous cell carcinoma of the head and neck (SCCHN) among non-Hispanic Whites.	2011-01-08
20935061	Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)	2010-12-05
20975315	DEC1 is down-regulated and tends to contribute to the migration ability of tumor cell lines; H3 K27 trimethylation potentially plays an important role in the regulation of DEC1 expression	2011-05-07
21317427	Study conclude that DeltaNp63 is a novel target of DEC1 and HDAC2 and modulates the efficacy of HDAC inhibitors in growth suppression and keratinocyte differentiation.	2011-07-23
21779800	DEC1 expression is correlated with HIF-1alpha protein in gastric cancer cell line.	2012-06-30
21829689	findings suggested that posttranslational modification of DEC1 in the form of SUMOylation may serve as a key factor that regulates the function of DEC1 in vivo	2011-12-31
22644784	IL-1beta can induce DEC1 and HIF-1alpha protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt phosphorylation.	2013-01-12
22723347	DEC1 controls the response of p53-dependent cell survival vs. cell death to a stress signal through MIC-1	2012-10-06
22728071	findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex	2012-10-20
22825629	These findings suggest that DEC1 plays an important role in the regulation of these EMT-related factors in pancreatic cancer.	2014-01-04
22844531	DEC1 overexpression in precursor lesions of esophageal squamous cell carcinoma is a protective mechanism	2012-12-08
23423709	Loss of DEC1 may promote tumor progression in non-small-cell lung cancer through upregulation of cyclin D1	2013-07-20
23578198	Sunitinib treatment performance could be attributable to TIS, depending on p53/Dec1 activation.	2014-02-15
24100543	The efficacy of inhibiting HIF-1alpha and DEC1 expression as a possible treatment for HCC should be assessed in clinical trials.	2014-05-17
24404147	DEC1 coordinates with HDAC8 to differentially regulate TAp73 and DeltaNp73 expression.	2014-09-20
24758579	The expression of DEC1 was associated with the incidence of oral squamous cell carcinoma (OSCC) and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.	2014-10-18
25202122	USP17 binds and deubiquitylates DEC1, markedly extending its half-life. Subsequently, during checkpoint recovery, DEC1 proteolysis is reestablished through betaTrCP-dependent ubiquitylation.	2015-02-14
25876658	DEC1 has a pro-apoptotic effect on human esophageal cancer TE 10 cells of well-differentiated type.	2016-01-16
Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser

Relevant citations within the PubMed literature

Showing 1-20 of 89 items.

Relevant PubMed citations

Pubmed ID	Title	Author	Publish Date

19624270	The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in gastric cancer. view abstract	Zheng Y, Jia Y, Wang Y, Wang M, Li B, Shi X, Ma X, Xiao D, Sun Y	2009-07-24
21779800	The increased expression of DEC1 gene is related to HIF-1alpha protein in gastric cancer cell lines. view abstract	Zheng Y, Shi X, Wang M, Jia Y, Li B, Zhang Y, Liu Q, Wang Y	2011-07-23
21829689	SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability. view abstract	Hong Y, Xing X, Li S, Bi H, Yang C, Zhao F, Liu Y, Ao X, Chang AK, Wu H	2011-08-11
21528084	DEC1 nuclear expression: a marker of differentiation grade in hepatocellular carcinoma. view abstract	Shi XH, Zheng Y, Sun Q, Cui J, Liu QH, Qu F, Wang YS	2011-04-30
19786558	The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. view abstract	Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, Kato Y, Makishima M	2009-09-30
26697751	Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. view abstract	Fujita Y, Makishima M, Bhawal UK	2015-12-25
23423709	The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells. view abstract	Liu Y, Wang L, Lin XY, Wang J, Yu JH, Miao Y, Wang EH	2013-02-21
17376295	Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1alpha, is another marker of lung tumor hypoxia. view abstract	Zhang L, Li QQ	2007-03-23
15560782	Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. view abstract	Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y	2004-11-25
12624110	DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. view abstract	Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B	2003-03-08
24100543	Hypoxia-induced overexpression of DEC1 is regulated by HIF-1alpha in hepatocellular carcinoma. view abstract	Ma W, Shi X, Lu S, Wu L, Wang Y	2013-10-09
22844531	Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. view abstract	Xu Q, Ma P, Hu C, Chen L, Xue L, Wang Z, Liu M, Zhu H, Xu N, Lu N	2012-07-31
22723347	Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. view abstract	Qian Y, Jung YS, Chen X	2012-06-23
21506129	Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1. view abstract	Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kijima H, Kuniyasu H, Abiko Y, Kato Y, Sato S	2011-04-21
21326238	Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis. view abstract	Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML	2011-02-18
18025081	DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. view abstract	Qian Y, Zhang J, Yan B, Chen X	2007-11-21
17943723	Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. view abstract	Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML	2007-10-19
16678499	Cloning and developmental expression of the DEC1 ortholog gene in zebrafish. view abstract	Yao J, Wang L, Chen L, Zhang S, Zhao Q, Jia W, Xue J	2006-05-09
16136500	DEC1 expression in 1p-aberrant oligodendroglial neoplasms. view abstract	Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA	2005-09-02
12384505	Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. view abstract	Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y	2002-10-18

Putative/known Functions

Localisation

Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db Name	Query Uni	Subject Uni	Sequence Length	Alignment Length	Identity	Coverage	Mismatches	Gap Openings	Query Start	Query End	Subject Start	Subject End	Evalue	Bit Score
All Reviewed Human	DEC1_HUMAN	DEC1_HUMAN	70	70	100	100	0	0	1	70	1	70	3.00E-36	146
Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR

gpmDB

	Peptide Sequence	Evidence Level	Log E	Number Of Observation	Spectra	Accession ID	Proteotypicity	Annotation
No results found.

Evidence File /mnt/mpp/ms_data/Q9P2X7_gpmdb.txt
Reference FenyÃ¶, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056â€“2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM

	Peptide Sequence	Evidence Level	Log E	Number Of Observation	Spectra	Accession ID	Proteotypicity	Annotation
	SIVPAPGEGLLAVLHMMVFTDALHR	red	-2.7	1	1	ENSP00000363128	Proteotypic
	SIVPAPGEGLLAVLHMMVFTDALHR	red	-2.7	1	1	ENSP00000363128	Proteotypic

Proteomics DB

	Peptide Sequence	Search Engine	Score	Threshold Score	Identification ID	Experiment ID	Annotation
No results found.

Evidence File /mnt/mpp/ms_data/Q9P2X7_protdb.txt
Reference Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. https://www.proteomicsdb.org/ ">Proteomics DB

Peptide Sequence	Search Engine	Score	Threshold Score	Identification ID	Experiment ID
MTMNVLEAGKWK	Maxquant	52.693	0	14250697	-1
TMNVLEAGKWK	Mascot	19.31	32	762721638	-1
DFAVSLARPK	Mascot	30.75	32	135119039	1