DEC1:Deleted in esophageal cancer 1

Gene Name Deleted in esophageal cancer 1	Protein ID Q9P2X7	Chromosome ID 9	HPP Status 2
Protein Name Deleted in esophageal cancer 1		Synonyms candidate tumor suppressor CTS9 CTS9 Candidate tumor suppressor CTS9 deleted in esophageal cancer 1 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEC1 ]
Chromosomal Position 9q33.1 \| Start:115141818 End:115141818		Sequence Q9P2X7.fasta
Description Entrez Gene Summary for DEC1 The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. (provided by RefSeq, Jul 2008) UniProtKB Summary for DEC1 Function: Candidate tumor suppressor [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEC1 ]
External IDs Hgnc ID: 23658 EntrezGene ID: 50514 Ensembl ID: ENSG00000173077 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DEC1 ]
Reference Source http://www.nextprot.org

Gene Reference Into Function (GeneRIF)

PubMed ID	GeneRIF Text	Last Update
15580306	DEC1 is a candidate tumor suppressor gene that may be involved in esophageal squamous cell carcinoma development	2010-01-21
17943723	Decreased expression of candidate DEC1 is associated with esophageal carcinoma	2010-01-21
19339270	Observational study of gene-disease association. (HuGE Navigator)	2009-04-22
19624270	The hypoxia-regulated transcription factor DEC1 and its expression in gastric cancer are reported.	2010-01-21
20379614	Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)	2010-06-30
20935061	DEC1 promoter -249 T>C (rs2012775) polymorphism is functional, modulating susceptibility to squamous cell carcinoma of the head and neck (SCCHN) among non-Hispanic Whites.	2011-01-08
20935061	Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)	2010-12-05
20975315	DEC1 is down-regulated and tends to contribute to the migration ability of tumor cell lines; H3 K27 trimethylation potentially plays an important role in the regulation of DEC1 expression	2011-05-07
21317427	Study conclude that DeltaNp63 is a novel target of DEC1 and HDAC2 and modulates the efficacy of HDAC inhibitors in growth suppression and keratinocyte differentiation.	2011-07-23
21779800	DEC1 expression is correlated with HIF-1alpha protein in gastric cancer cell line.	2012-06-30
21829689	findings suggested that posttranslational modification of DEC1 in the form of SUMOylation may serve as a key factor that regulates the function of DEC1 in vivo	2011-12-31
22644784	IL-1beta can induce DEC1 and HIF-1alpha protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt phosphorylation.	2013-01-12
22723347	DEC1 controls the response of p53-dependent cell survival vs. cell death to a stress signal through MIC-1	2012-10-06
22728071	findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex	2012-10-20
22825629	These findings suggest that DEC1 plays an important role in the regulation of these EMT-related factors in pancreatic cancer.	2014-01-04
22844531	DEC1 overexpression in precursor lesions of esophageal squamous cell carcinoma is a protective mechanism	2012-12-08
23423709	Loss of DEC1 may promote tumor progression in non-small-cell lung cancer through upregulation of cyclin D1	2013-07-20
23578198	Sunitinib treatment performance could be attributable to TIS, depending on p53/Dec1 activation.	2014-02-15
24100543	The efficacy of inhibiting HIF-1alpha and DEC1 expression as a possible treatment for HCC should be assessed in clinical trials.	2014-05-17
24404147	DEC1 coordinates with HDAC8 to differentially regulate TAp73 and DeltaNp73 expression.	2014-09-20
24758579	The expression of DEC1 was associated with the incidence of oral squamous cell carcinoma (OSCC) and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.	2014-10-18
25202122	USP17 binds and deubiquitylates DEC1, markedly extending its half-life. Subsequently, during checkpoint recovery, DEC1 proteolysis is reestablished through betaTrCP-dependent ubiquitylation.	2015-02-14
25876658	DEC1 has a pro-apoptotic effect on human esophageal cancer TE 10 cells of well-differentiated type.	2016-01-16
Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser

Relevant citations within the PubMed literature

Total 89 items.

Relevant PubMed citations

Pubmed ID	Title	Author	Publish Date

17097613	Molecular analysis of Dec1 and Dec2 in the peripheral circadian clock of zebrafish photosensitive cells. view abstract	Abe T, Ishikawa T, Masuda T, Mizusawa K, Tsukamoto T, Mitani H, Yanagisawa T, Todo T, Iigo M	2006-11-14
22644784	IL-1beta-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway. view abstract	Bhawal UK, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, Sasahira T, Hamada N, Kuniyasu H, Arakawa H, Kato Y, Abiko Y	2012-05-31
21506129	Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1. view abstract	Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kijima H, Kuniyasu H, Abiko Y, Kato Y, Sato S	2011-04-21
26402517	DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase. view abstract	Bi H, Li S, Qu X, Wang M, Bai X, Xu Z, Ao X, Jia Z, Jiang X, Yang Y, Wu H	2015-09-25
3936099	Schedule-controlled behavior as an index of the development and loss of ethanol tolerance in the rat. view abstract	Bird DC, Holloway FA, Carney JM	1985-01-01
15038852	Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice. view abstract	Butler MP, Honma S, Fukumoto T, Kawamoto T, Fujimoto K, Noshiro M, Kato Y, Honma K	2004-03-25
15328513	The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers. view abstract	Chakrabarti J, Turley H, Campo L, Han C, Harris AL, Gatter KC, Fox SB	2004-08-26
16918041	Hypoxic treatment inhibits insulin-induced chondrogenesis of ATDC5 cells despite upregulation of DEC1. view abstract	Chen L, Fink T, Ebbesen P, Zachar V	2006-08-22
25801056	Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1alpha/Stra13 pathway. view abstract	Chen R, Wang Y, Ning R, Hu J, Liu W, Xiong J, Wu L, Liu J, Hu G, Yang J	2015-03-25
19786558	The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. view abstract	Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, Kato Y, Makishima M	2009-09-30
18838394	Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism. view abstract	Choi SM, Cho HJ, Cho H, Kim KH, Kim JB, Park H	2008-10-08
17942899	Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. view abstract	Ehata S, Hanyu A, Hayashi M, Aburatani H, Kato Y, Fujime M, Saitoh M, Miyazawa K, Imamura T, Miyazono K	2007-10-19
11162494	Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. view abstract	Fujimoto K, Shen M, Noshiro M, Matsubara K, Shingu S, Honda K, Yoshida E, Suardita K, Matsuda Y, Kato Y	2001-02-13
26697751	Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. view abstract	Fujita Y, Makishima M, Bhawal UK	2015-12-25
26183399	Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread. view abstract	Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D, Chiarugi P	2015-07-18
12754744	DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. view abstract	Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL	2003-05-20
21829689	SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability. view abstract	Hong Y, Xing X, Li S, Bi H, Yang C, Zhao F, Liu Y, Ao X, Chang AK, Wu H	2011-08-11
25575296	Differentiated embryonic chondrocytes 1 expression of periodontal ligament tissue and gingival tissue in the patients with chronic periodontitis. view abstract	Hu S, Shang W, Yue H, Chen R, Dong Z, Hu J, Mao Z, Yang J	2015-01-10
20935061	A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck. view abstract	Huang YJ, Niu J, Wei S, Yin M, Liu Z, Wang LE, Sturgis EM, Wei Q	2010-10-12
23445622	Differentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1alpha and Ki67 in human gastric cancer. view abstract	Jia YF, Xiao DJ, Ma XL, Song YY, Hu R, Kong Y, Zheng Y, Han SY, Hong RL, Wang YS	2013-03-01
24397494	Down regulation of differentiated embryo-chondrocyte expressed gene 1 is related to the decrease of osteogenic capacity. view abstract	Jinhua H, Zhao M, Wei S, Haitao Y, Yuwen W, Lili W, Wei L, Jian Y	2014-01-09
25248482	DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli. view abstract	Kato Y, Kawamoto T, Fujimoto K, Noshiro M	2014-09-25
17611704	Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. view abstract	Katoh M, Katoh M	2007-07-06
25202122	USP17- and SCFbetaTrCP--regulated degradation of DEC1 controls the DNA damage response. view abstract	Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D	2014-09-10
20975315	Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines. view abstract	Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimura M, Kitano H	2010-10-27
17943723	Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. view abstract	Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML	2007-10-19
24557623	Ultravlolet-B induced expression of hypoxia-inducible factor 1alpha, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway. view abstract	Li Y, Bi Z	2014-02-22
16964427	UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway. view abstract	Li Y, Bi Z, Yan B, Wan Y	2006-09-12
15193144	DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. view abstract	Li Y, Song X, Ma Y, Liu J, Yang D, Yan B	2004-06-15
12624110	DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. view abstract	Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B	2003-03-08
16462771	The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. view abstract	Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B	2006-02-08
12119049	Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. view abstract	Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B	2002-07-18
18461556	Prostaglandin F2alpha induces the normoxic activation of the hypoxia-inducible factor-1 transcription factor in differentiating 3T3-L1 preadipocytes: Potential role in the regulation of adipogenesis. view abstract	Liu L, Clipstone NA	2008-05-08
23426649	DEC1 is positively associated with the malignant phenotype of invasive breast cancers and negatively correlated with the expression of claudin-1. view abstract	Liu Y, Miao Y, Wang J, Lin X, Wang L, Xu HT, Wang EH	2013-02-22
20236182	Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. view abstract	Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, Kondo J, Wu Y, Noshiro M, Kato Y, Kijima H	2010-03-19
23423709	The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells. view abstract	Liu Y, Wang L, Lin XY, Wang J, Yu JH, Miao Y, Wang EH	2013-02-21
24100543	Hypoxia-induced overexpression of DEC1 is regulated by HIF-1alpha in hepatocellular carcinoma. view abstract	Ma W, Shi X, Lu S, Wu L, Wang Y	2013-10-09
22728071	DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. view abstract	Mao Z, Luan X, Cao G, Liu W, Xiong J, Hu G, Chen R, Ning R, Shang W, Yang J, Yan B	2012-06-26
23878307	CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. view abstract	Martinez-Llordella M, Esensten JH, Bailey-Bucktrout SL, Lipsky RH, Marini A, Chen J, Mughal M, Mattson MP, Taub DD, Bluestone JA	2013-07-24
12354771	Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. view abstract	Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y	2002-10-02
18345027	Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. view abstract	Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, Yoshiga K, Poellinger L, Hiyama E, Nishiyama M	2008-03-18
18411297	DEC1 modulates the circadian phase of clock gene expression. view abstract	Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, Kohno N, Kato Y	2008-04-16
10612805	Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. view abstract	Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y	1999-12-29
21896344	HIF-1alpha induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice. view abstract	Nishiyama Y, Goda N, Kanai M, Niwa D, Osanai K, Yamamoto Y, Senoo-Matsuda N, Johnson RS, Miura S, Kabe Y, Suematsu M	2011-09-08
15066123	Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP. view abstract	Noshiro M, Kawamoto T, Furukawa M, Fujimoto K, Yoshida Y, Sasabe E, Tsutsumi S, Hamada T, Honma S, Honma K, Kato Y	2004-04-07
19032342	Liver X receptors (LXRalpha and LXRbeta) are potent regulators for hepatic Dec1 expression. view abstract	Noshiro M, Usui E, Kawamoto T, Sato F, Nakashima A, Ueshima T, Honda K, Fujimoto K, Honma S, Honma K, Makishima M, Kato Y	2008-11-27
22244086	Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORalpha and their roles in adipogenesis. view abstract	Ozaki N, Noshiro M, Kawamoto T, Nakashima A, Honda K, Fukuzaki-Dohi U, Honma S, Fujimoto K, Tanimoto K, Tanne K, Kato Y	2012-01-17
22610404	Differentiated embryo chondrocyte 1 (DEC1) represses PPARgamma2 gene through interacting with CCAAT/enhancer binding protein beta (C/EBPbeta). view abstract	Park YK, Park H	2012-05-22
22796345	Down regulation of differentiated embryonic chondrocytes 1 (DEC1) is involved in 8-methoxypsoralen-induced apoptosis in HepG2 cells. view abstract	Peng Y, Liu W, Xiong J, Gui HY, Feng XM, Chen RN, Hu G, Yang J	2012-07-17
16136500	DEC1 expression in 1p-aberrant oligodendroglial neoplasms. view abstract	Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA	2005-09-02
18556654	ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. view abstract	Qian Y, Chen X	2008-06-17
22723347	Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. view abstract	Qian Y, Jung YS, Chen X	2012-06-23
21317427	DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. view abstract	Qian Y, Jung YS, Chen X	2011-02-15
24404147	DEC1 coordinates with HDAC8 to differentially regulate TAp73 and DeltaNp73 expression. view abstract	Qian Y, Zhang J, Jung YS, Chen X	2014-01-10
18025081	DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. view abstract	Qian Y, Zhang J, Yan B, Chen X	2007-11-21
12236595	A decarboxylase encoded at the Cochliobolus heterostrophus translocation-associated Tox1B locus is required for polyketide (T-toxin) biosynthesis and high virulence on T-cytoplasm maize. view abstract	Rose MS, Yun SH, Asvarak T, Lu SW, Yoder OC, Turgeon BG	2002-09-19
18233956	Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression. view abstract	Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Imaizumi T, Imanaka T, Kondo J, Koyanagi S, Noshiro M, Yoshida H, Kusumi T, Kato Y, Kijima H	2008-02-01
26819638	DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression. view abstract	Sato F, Bhawal UK, Yoshimura T, Muragaki Y	2016-01-29
15560782	Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. view abstract	Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y	2004-11-25
26498531	DEC1 negatively regulates AMPK activity via LKB1. view abstract	Sato F, Muragaki Y, Zhang Y	2015-10-27
15114665	Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice. view abstract	Seimiya M, Wada A, Kawamura K, Sakamoto A, Ohkubo Y, Okada S, Hatano M, Tokuhisa T, Watanabe T, Saisho H, Tagawa M, O-Wang J	2004-04-29
25876658	Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells. view abstract	Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, Takai Y, Kijima H	2015-04-17
26340669	Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells. view abstract	Shang W, Liu J, Chen R, Ning R, Xiong J, Liu W, Mao Z, Hu G, Yang J	2015-09-05
24993831	Hepatic differentiated embryo-chondrocyte-expressed gene 1 (Dec1) inhibits sterol regulatory element-binding protein-1c (Srebp-1c) expression and alleviates fatty liver phenotype. view abstract	Shen L, Cui A, Xue Y, Cui Y, Dong X, Gao Y, Yang H, Fang F, Chang Y	2014-07-05
11432722	Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway. view abstract	Shen M, Kawamoto T, Teramoto M, Makihira S, Fujimoto K, Yan W, Noshiro M, Kato Y	2001-07-04
9240428	Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. view abstract	Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y	1997-07-18
12384505	Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. view abstract	Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y	2002-10-18
20214949	Possible involvement of DEC1 on the adverse effects of quinolone antibiotics. view abstract	Shi X, Zheng Y, Ma W, Wang Y	2010-03-11
21528084	DEC1 nuclear expression: a marker of differentiation grade in hepatocellular carcinoma. view abstract	Shi XH, Zheng Y, Sun Q, Cui J, Liu QH, Qu F, Wang YS	2011-04-30
21430977	Development of a Cognitive Level Explanation Model in Brain Injury : Comparisons between Disability and Non-Disability Evaluation Groups. view abstract	Shin TH, Gong CB, Kim MS, Kim JS, Bai DS, Kim OL	2011-03-25
11226878	Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2. view abstract	Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, Tsutsumi S, Kawamoto T, Iwamoto Y, Kato Y	2001-02-28
15221940	The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours. view abstract	Turley H, Wykoff CC, Troup S, Watson PH, Gatter KC, Harris AL	2004-06-29
22960268	Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES1. view abstract	Ueshima T, Kawamoto T, Honda KK, Noshiro M, Fujimoto K, Nakao S, Ichinose N, Hashimoto S, Gotoh O, Kato Y	2012-09-11
22517515	MicroRNA target site polymorphisms in the VHL-HIF1alpha pathway predict renal cell carcinoma risk. view abstract	Wei H, Ke HL, Lin J, Shete S, Wood CG, Hildebrandt MA	2012-04-21
21326238	Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis. view abstract	Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML	2011-02-18
27035755	Podoplanin-mediated TGF-beta-induced epithelial-mesenchymal transition and its correlation with bHLH transcription factor DEC in TE-11 cells. view abstract	Wu Y, Liu Q, Yan X, Kato Y, Tanaka M, Inokuchi S, Yoshizawa T, Morohashi S, Kijima H	2016-04-02
21327324	Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells. view abstract	Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Morohashi S, Kato Y, Kijima H	2011-02-18
22572381	BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells. view abstract	Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Seino H, Morohashi S, Kato Y, Kijima H	2012-05-11
22825629	The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer. view abstract	Wu Y, Sato F, Yamada T, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Seino H, Morohashi S, Hakamada K, Abiko Y, Kato Y, Kijima H	2012-07-25
25524285	Involvement of c-Myc in the proliferation of MCF-7 human breast cancer cells induced by bHLH transcription factor DEC2. view abstract	Wu Y, Sato H, Suzuki T, Yoshizawa T, Morohashi S, Seino H, Kawamoto T, Fujimoto K, Kato Y, Kijima H	2014-12-20
26808085	The anti-metastatic effect of 8-MOP on hepatocellular carcinoma is potentiated by the down-regulation of bHLH transcription factor DEC1. view abstract	Xiong J, Yang H, Luo W, Shan E, Liu J, Zhang F, Xi T, Yang J	2016-01-26
22844531	Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. view abstract	Xu Q, Ma P, Hu C, Chen L, Xue L, Wang Z, Liu M, Zhu H, Xu N, Lu N	2012-07-31
15580306	Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. view abstract	Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML	2004-12-08
16678499	Cloning and developmental expression of the DEC1 ortholog gene in zebrafish. view abstract	Yao J, Wang L, Chen L, Zhang S, Zhao Q, Jia W, Xue J	2006-05-09
24758579	The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma. view abstract	You J, Lin L, Liu Q, Zhu T, Xia K, Su T	2014-04-25
11880636	DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities. view abstract	Zawel L, Yu J, Torrance CJ, Markowitz S, Kinzler KW, Vogelstein B, Zhou S	2002-03-07
17376295	Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1alpha, is another marker of lung tumor hypoxia. view abstract	Zhang L, Li QQ	2007-03-23
19624270	The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in gastric cancer. view abstract	Zheng Y, Jia Y, Wang Y, Wang M, Li B, Shi X, Ma X, Xiao D, Sun Y	2009-07-24
21779800	The increased expression of DEC1 gene is related to HIF-1alpha protein in gastric cancer cell lines. view abstract	Zheng Y, Shi X, Wang M, Jia Y, Li B, Zhang Y, Liu Q, Wang Y	2011-07-23

Putative/known Functions

Localisation

Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db Name	Query Uni	Subject Uni	Sequence Length	Alignment Length	Identity	Coverage	Mismatches	Gap Openings	Query Start	Query End	Subject Start	Subject End	Evalue	Bit Score
All Reviewed Human	DEC1_HUMAN	DEC1_HUMAN	70	70	100	100	0	0	1	70	1	70	3.00E-36	146
Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR

gpmDB

	Peptide Sequence	Evidence Level	Log E	Number Of Observation	Spectra	Accession ID	Proteotypicity	Annotation
No results found.

Evidence File /mnt/mpp/ms_data/Q9P2X7_gpmdb.txt
Reference FenyÃ¶, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056â€“2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM

	Peptide Sequence	Evidence Level	Log E	Number Of Observation	Spectra	Accession ID	Proteotypicity	Annotation
	SIVPAPGEGLLAVLHMMVFTDALHR	red	-2.7	1	1	ENSP00000363128	Proteotypic
	SIVPAPGEGLLAVLHMMVFTDALHR	red	-2.7	1	1	ENSP00000363128	Proteotypic

Proteomics DB

	Peptide Sequence	Search Engine	Score	Threshold Score	Identification ID	Experiment ID	Annotation
No results found.

Evidence File /mnt/mpp/ms_data/Q9P2X7_protdb.txt
Reference Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. https://www.proteomicsdb.org/ ">Proteomics DB

Peptide Sequence	Search Engine	Score	Threshold Score	Identification ID	Experiment ID
MTMNVLEAGKWK	Maxquant	52.693	0	14250697	-1
TMNVLEAGKWK	Mascot	19.31	32	762721638	-1
DFAVSLARPK	Mascot	30.75	32	135119039	1