PRRX2:Paired mesoderm homeobox protein 2
|
Gene Name
Paired mesoderm homeobox protein 2 |
Protein ID
Q99811 |
Chromosome ID
9 |
HPP Status
2 |
|
Protein Name
Paired mesoderm homeobox protein 2 |
Synonyms
PMX2 Paired-related homeobox protein 2 paired related homeobox 2 PRX-2 paired-like homeodomain protein PRX2 PRX2 paired-related homeobox protein 2 paired mesoderm homeobox protein 2 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRRX2  ] |
||
|
Chromosomal Position
9q34.11 | Start:129665641 End:129665641 |
Sequence
Q99811.fasta |
||
|
Description
Entrez Gene Summary for PRRX2The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. (provided by RefSeq, Jul 2008) UniProtKB Summary for PRRX2Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRRX2 ] |
|||
|
External IDs
Hgnc ID: 21338 EntrezGene ID: 51450 Ensembl ID: ENSG00000167157 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRRX2 ] |
|||
|
Reference Source
http://www.nextprot.org |
|||
Gene Reference Into Function (GeneRIF)
| PubMed ID | GeneRIF Text | Last Update |
|---|---|---|
| 11893718 | Encodes homeobox transcription factors that are expressed during vasculogenesis. | 2010-01-21 |
| 17964282 | Valsartan, a selective Ang II type 1 (AT1) receptor blocker, and N-acetylcysteine, an antioxidant, inhibited both of these modifications, indicating the contribution of AT1 receptor and reactive oxygen species to oxidation of Prx2. | 2010-01-21 |
| 20634891 | Observational study of gene-disease association. (HuGE Navigator) | 2010-09-15 |
| 21385867 | Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study. | 2011-07-30 |
| Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ | ||
OMICSDI Browser
Relevant citations within the PubMed literature
