Gene Name
Calpain-12 |
Protein ID
Q6ZSI9 |
Chromosome ID
19 |
HPP Status
1 |
Protein Name
Calpain-12 |
Synonyms
calcium-activated neutral proteinase 12 calpain-12 CANP 12 Calcium-activated neutral proteinase 12 calpain 12 EC 3.4.22.- [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN12 ![]() |
||
Chromosomal Position
19q13.2 | Start:38730187 End:38730187 |
Sequence
Q6ZSI9.fasta |
||
Description
Entrez Gene Summary for CAPN12The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. (provided by RefSeq, Jun 2012) UniProtKB Summary for CAPN12Function: Calcium-regulated non-lysosomal thiol-protease (By similarity) Tocris Summary for CAPN12 Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3). [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN12 ![]() |
|||
External IDs
Hgnc ID: 13249 EntrezGene ID: 147968 Ensembl ID: ENSG00000182472 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN12 ![]() |
|||
Reference Source
http://www.nextprot.org ![]() |
|||