HELT:Hairy and enhancer of split-related protein HELT
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Gene Name
Hairy and enhancer of split-related protein HELT |
Protein ID
A6NFD8 |
Chromosome ID
4 |
HPP Status
2 |
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Protein Name
Hairy and enhancer of split-related protein HELT |
Synonyms
"HES-like" Hey-like transcription factor (zebrafish) Megane bHLH factor hairy and enhancer of split-related protein HELT Mgn HES/HEY-like transcription factor bHLHb44 Hey-like transcription factor helt bHLH transcription factor HCM1228 "megane bHLH factor" Hey-like transcriptional repressor HESL Heslike [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HELT  ] |
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Chromosomal Position
4q35.1 | Start:185018841 End:185018841 |
Sequence
A6NFD8.fasta |
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Description
UniProtKB Summary for HELTFunction: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By similarity) [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HELT ] |
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External IDs
Hgnc ID: 33783 EntrezGene ID: 391723 Ensembl ID: ENSG00000187821 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HELT ] |
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Reference Source
http://www.nextprot.org |
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Gene Reference Into Function (GeneRIF)
| PubMed ID | GeneRIF Text | Last Update |
|---|---|---|
| 15375612 | identified and characterized human HES-like (HESL), rat hesl, and rainbow trout hesl genes by using bioinformatics | 2010-01-21 |
| Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ | ||
OMICSDI Browser
Relevant citations within the PubMed literature
Putative/known Functions
Localisation
Homologues, Orthologues, Paralogues and Family
Sequence Similarity and Functional Annotation
Sequence Similarity
| Db Name | Query Uni | Subject Uni | Sequence Length | Alignment Length | Identity | Coverage | Mismatches | Gap Openings | Query Start | Query End | Subject Start | Subject End | Evalue | Bit Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reviewed non-human mammalian with experimental evidence | HELT_HUMAN | HELT_MOUSE | 327 | 278 | 77.34 | 85.02 | 20 | 3 | 50 | 327 | 6 | 240 | 2E-97 | 351 |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||||||||||
InterProScan Annotation
| Uniprot ID | Interpro ID | Go ID | Type | Name | Category | Description |
|---|---|---|---|---|---|---|
| HELT_HUMAN | IPR003650 | GO:0003677 | Domain | Orange | Molecular Function | DNA binding |
| HELT_HUMAN | IPR011598 | GO:0046983 | Domain | Myc-type, basic helix-loop-helix (bHLH) domain | Molecular Function | protein dimerization activity |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||