ABCA10:ATP-binding cassette sub-family A member 10
|
Gene Name
ATP-binding cassette sub-family A member 10 |
Protein ID
Q8WWZ4 |
Chromosome ID
17 |
HPP Status
2 |
|
Protein Name
ATP-binding cassette sub-family A member 10 |
Synonyms
ATP-binding cassette sub-family A member 10 ATP-binding cassette A10 ATP-binding cassette, sub-family A (ABC1), member 10 EST698739 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABCA10  ] |
||
|
Chromosomal Position
17q24.3 | Start:69147214 End:69147214 |
Sequence
Q8WWZ4.fasta |
||
|
Description
Entrez Gene Summary for ABCA10The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. (provided by RefSeq, Jul 2008) UniProtKB Summary for ABCA10Function: Probable transporter which may play a role in macrophage lipid homeostasis [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABCA10 ] |
|||
|
External IDs
Hgnc ID: 30 EntrezGene ID: 10349 Ensembl ID: ENSG00000154263 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABCA10 ] |
|||
|
Reference Source
http://www.nextprot.org |
|||
Gene Reference Into Function (GeneRIF)
| PubMed ID | GeneRIF Text | Last Update |
|---|---|---|
| 12821155 | ABCA10 is a novel member of the group of ABCA6-like transporters involved in macrophage lipid homeostasis | 2010-01-21 |
| 25294155 | Results suggest a possible role for multidrug resistance genes ABCA10 and ABCA6 in follicular lymphoma survival and add to the evidence that genetic variation in CD46 and IL8 may have prognostic implications follicular lymphoma. | 2015-07-04 |
| Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ | ||
OMICSDI Browser
Relevant citations within the PubMed literature
Putative/known Functions
Localisation
Homologues, Orthologues, Paralogues and Family
Sequence Similarity and Functional Annotation
Sequence Similarity
| Db Name | Query Uni | Subject Uni | Sequence Length | Alignment Length | Identity | Coverage | Mismatches | Gap Openings | Query Start | Query End | Subject Start | Subject End | Evalue | Bit Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reviewed non-human mammalian with experimental evidence | ABCAA_HUMAN | ABCA9_MOUSE | 1543 | 1544 | 60.04 | 100.06 | 603 | 6 | 1 | 1542 | 91 | 1622 | 0.00E+00 | 1786 |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||||||||||
InterProScan Annotation
| Uniprot ID | Interpro ID | Go ID | Type | Name | Category | Description |
|---|---|---|---|---|---|---|
| ABCAA_HUMAN | IPR003439 | GO:0005524 | Domain | ABC transporter-like | Molecular Function | ATP binding |
| ABCAA_HUMAN | IPR003439 | GO:0016887 | Domain | ABC transporter-like | Molecular Function | ATPase activity |
| ABCAA_HUMAN | IPR003593 | GO:0000166 | Domain | AAA+ ATPase domain | Molecular Function | nucleotide binding |
| ABCAA_HUMAN | IPR003593 | GO:0017111 | Domain | AAA+ ATPase domain | Molecular Function | nucleoside-triphosphatase activity |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||
KEGG Pathways
| Pathway ID | Database Name | Pathway Name |
|---|---|---|
| hsa02010 | KEGG PATHWAY | ABC transporters |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||