ABCA10:ATP-binding cassette sub-family A member 10

Gene Name
ATP-binding cassette sub-family A member 10
Protein ID
Q8WWZ4
Chromosome ID
17
HPP Status
2
Protein Name
ATP-binding cassette sub-family A member 10
Synonyms

ATP-binding cassette sub-family A member 10

ATP-binding cassette A10

ATP-binding cassette, sub-family A (ABC1), member 10

EST698739


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABCA10 ]
Chromosomal Position
17q24.3 | Start:69147214 End:69147214
Sequence
Q8WWZ4.fasta
Description

Entrez Gene Summary for ABCA10
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ABCA10
Function: Probable transporter which may play a role in macrophage lipid homeostasis

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABCA10 ]
External IDs
Hgnc ID: 30 EntrezGene ID: 10349 Ensembl ID: ENSG00000154263
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABCA10 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12821155ABCA10 is a novel member of the group of ABCA6-like transporters involved in macrophage lipid homeostasis2010-01-21
25294155Results suggest a possible role for multidrug resistance genes ABCA10 and ABCA6 in follicular lymphoma survival and add to the evidence that genetic variation in CD46 and IL8 may have prognostic implications follicular lymphoma.2015-07-04
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceABCAA_HUMANABCA9_MOUSE1543154460.04100.066036115429116220.00E+001786
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ABCAA_HUMANIPR003439GO:0005524DomainABC transporter-likeMolecular FunctionATP binding
ABCAA_HUMANIPR003439GO:0016887DomainABC transporter-likeMolecular FunctionATPase activity
ABCAA_HUMANIPR003593GO:0000166DomainAAA+ ATPase domainMolecular Functionnucleotide binding
ABCAA_HUMANIPR003593GO:0017111DomainAAA+ ATPase domainMolecular Functionnucleoside-triphosphatase activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa02010KEGG PATHWAYABC transporters
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Total 4 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
LFPQAAWQERgreen-6.931ENSP00000269081Proteotypic
LFPQAAWQERgreen-6.931ENSP00000269081Proteotypic
LFPQAAWQERgreen-6.931ENSP00000269081Proteotypic
LFPQAAWQERgreen-6.931ENSP00000269081Proteotypic
Evidence File
/mnt/mpp/ms_data/Q8WWZ4_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-2 of 2 items.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
CAGSSLFLKR2.63795452347414E-4,Mascot:expectation;45.05,Mascot:score;PXD001694_43447_5700_Q8WWZ4_CAGSSLFLKRPXD001694;A549 _20140715_xinku_MGFPeaklist.mgf;index=38283
CAGSSLFLKR0.00265507262113921,Mascot:expectation;33.52,Mascot:score;PXD001694_43449_7280_Q8WWZ4_CAGSSLFLKRPXD001694;DataSETH1299_MGFPeaklist.mgf;index=41732
Evidence File
/mnt/mpp/ms_data/Q8WWZ4_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8WWZ4_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB