KLHL1:Kelch-like protein 1
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Gene Name
Kelch-like protein 1 |
Protein ID
Q9NR64 |
Chromosome ID
13 |
HPP Status
2 |
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Protein Name
Kelch-like protein 1 |
Synonyms
kelch-like 1 (Drosophila) MRP2 "Kelch-like protein 1" KIAA1490 kelch-like protein 1 Mayven-related protein 2 kelch (Drosophila)-like 1 "Mayven-related protein 2" kelch-like family member 1 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLHL1  ] |
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Chromosomal Position
13q21.33 | Start:69700594 End:69700594 |
Sequence
Q9NR64.fasta |
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Description
Entrez Gene Summary for KLHL1The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000 (PubMed 10888605)).(supplied by OMIM, Feb 2010) UniProtKB Summary for KLHL1Function: May play a role in organizing the actin cytoskeleton of the brain cells [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLHL1 ] |
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External IDs
Hgnc ID: 6352 EntrezGene ID: 57626 Ensembl ID: ENSG00000150361 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLHL1 ] |
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Reference Source
http://www.nextprot.org |
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Gene Reference Into Function (GeneRIF)
| PubMed ID | GeneRIF Text | Last Update |
|---|---|---|
| 16982692 | This study provides, for the first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-dependent manner. | 2010-01-21 |
| 17289272 | modulatory effect of KLHL1 on the P/Q-type calcium channel function, suggesting a possible novel role for KLHL1 in cellular excitability. | 2010-01-21 |
| 18708037 | KLHL1 was expressed in human brain and kidney, but was also in other tissues, such as prostate gland, small intestine, colon, testis (but not the ovaries), liver and pancreas. | 2010-01-21 |
| 20147652 | KLHL1 interacts with Cav3.2 and modulates T-type calcium currents by increasing current deactivation kinetics and current density and calcium influx. | 2010-06-28 |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 2010-06-30 |
| 21427078 | Renal transplant recipients T carriers of C24T MRP2 with macrolides treatment were associated with reduced mycophenolic acid area under curve in steady-state conditions | 2012-06-02 |
| Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ | ||
OMICSDI Browser
Relevant citations within the PubMed literature
Putative/known Functions
Localisation
Homologues, Orthologues, Paralogues and Family
Sequence Similarity and Functional Annotation
Sequence Similarity
| Db Name | Query Uni | Subject Uni | Sequence Length | Alignment Length | Identity | Coverage | Mismatches | Gap Openings | Query Start | Query End | Subject Start | Subject End | Evalue | Bit Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reviewed non-human mammalian with experimental evidence | KLHL1_HUMAN | KLHL1_MOUSE | 748 | 751 | 95.21 | 100.4 | 33 | 2 | 1 | 748 | 1 | 751 | 0.00E+00 | 1326 |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||||||||||
InterProScan Annotation
| Uniprot ID | Interpro ID | Go ID | Type | Name | Category | Description |
|---|---|---|---|---|---|---|
| KLHL1_HUMAN | IPR000210 | GO:0005515 | Domain | BTB/POZ-like | Molecular Function | protein binding |
| KLHL1_HUMAN | IPR006652 | GO:0005515 | Repeat | Kelch repeat type 1 | Molecular Function | protein binding |
| KLHL1_HUMAN | IPR013069 | GO:0005515 | Domain | BTB/POZ | Molecular Function | protein binding |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||