QRFP:Orexigenic neuropeptide QRFP

Gene Name Orexigenic neuropeptide QRFP	Protein ID P83859	Chromosome ID 9	HPP Status 2
Protein Name Orexigenic neuropeptide QRFP		Synonyms P518 precursor protein RF(Arg-Phe)amide family 26 amino acid peptide (P518) prepro-QRFP "prepro-QRFP" 26RFA pyroglutamylated RFamide peptide P518 26RFa orexigenic neuropeptide QRFP [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ]
Chromosomal Position 9q34.12 \| Start:130892702 End:130892702		Sequence P83859.fasta
Description Entrez Gene Summary for QRFP The P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including P518. RF-amide peptides share a common C-terminal motif and are involved in cell signaling through G protein-coupled receptors (Jiang et al., 2003 (PubMed 12714592)).(supplied by OMIM, Mar 2008) UniProtKB Summary for QRFP Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity) [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ]
External IDs Hgnc ID: 29982 EntrezGene ID: 347148 Ensembl ID: ENSG00000188710 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ]
Reference Source http://www.nextprot.org

Gene Reference Into Function (GeneRIF)

PubMed ID	GeneRIF Text	Last Update
12714592	P518 exhibited high affinity for SP9155. The peptide P518 precursor gene is predominantly expressed in various brain regions, coronary arteries, thyroid and parathyroid glands, large intestine, colon, bladder, testes, and prostate.	2010-01-21
15808908	Solution conformation of 26RFa by using two-dimensional NMR spectroscopy in different media was investigated.	2010-01-21
15891009	A bioinformatic search for peptides related to frog 26RFa reveals the presence of homologous sequences in the human genome.	2010-01-21
16899066	Characterization of 26RFa-related peptides showed that two distinct molecular forms of 26RFa are present in the human hypothalamus and spinal cord, i.e. 26RFa and an N-terminally elongated form of 43 amino acids designated 43RFa.	2010-01-21
20534693	Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.	2010-11-27
22466335	High levels of circulating 26RFa observed in anorexia nervosa patients might reflect an adaptive mechanism of the organism to promote energy intake and to increase fat stores in response to undernutrition.	2012-08-18
22863147	Data indicate that 26RFa may participate to the development of prostate cancer at the androgen independent state by promoting the neuroendocrine differentiation and the migration of cancer cells via autocrine/paracrine mechanisms.	2013-05-11
25858563	we show a moderate positive correlation between plasma 26RFa levels and insulin in patients with diabetes. Plasma 26RFa increases in response to glucose tolerance test. 26RFa and its receptor GPR103 are present in human pancreatic beta-cells and gut.	2015-10-10
Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser

Relevant citations within the PubMed literature

Showing 1-20 of 28 items.

Relevant PubMed citations

Pubmed ID	Title	Author	Publish Date

26823127	The effects of high fat diet and estradiol on hypothalamic prepro-QRFP mRNA expression in female rats. view abstract	Schreiber AL, Arceneaux KP 3rd, Malbrue RA, Mouton AJ, Chen CS, Bench EM, Braymer HD, Primeaux SD	2016-01-30
25895849	QRFP-26 enhances insulin's effects on glucose uptake in rat skeletal muscle cells. view abstract	Allerton TD, Primeaux SD	2015-04-22
24284825	Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia. view abstract	Jossart C, Mulumba M, Granata R, Gallo D, Ghigo E, Marleau S, Servant MJ, Ong H	2013-11-29
25677823	QRFP-43 inhibits lipolysis by preventing ligand-induced complex formation between perilipin A, caveolin-1, the catalytic subunit of protein kinase and hormone-sensitive lipase in 3T3-L1 adipocytes. view abstract	Mulumba M, Granata R, Marleau S, Ong H	2015-02-14
25386115	Unexpected multiplicity of QRFP receptors in early vertebrate evolution. view abstract	Larhammar D, Xu B, Bergqvist CA	2014-11-12
21473894	QRFP in female rats: effects on high fat food intake and hypothalamic gene expression across the estrous cycle. view abstract	Primeaux SD	2011-04-09
18765262	Central administration of the RFamide peptides, QRFP-26 and QRFP-43, increases high fat food intake in rats. view abstract	Primeaux SD, Blackmon C, Barnes MJ, Braymer HD, Bray GA	2008-09-04
26865608	QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish. view abstract	Chen A, Chiu CN, Mosser EA, Kahn S, Spence R, Prober DA	2016-02-12
19428995	Molecular cloning and functional characterization of the first non-mammalian 26RFa/QRFP orthologue in Goldfish, Carassius auratus. view abstract	Liu Y, Zhang Y, Li S, Huang W, Liu X, Lu D, Meng Z, Lin H	2009-05-12
25102021	Molecular cloning, characterization and functional analysis of QRFP in orange-spotted grouper (Epinephelus coioides). view abstract	Shu H, Chen H, Liu Y, Yang L, Yang Y, Zhang H	2014-08-08
16996040	Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat. view abstract	Kampe J, Wiedmer P, Pfluger PT, Castaneda TR, Burget L, Mondala H, Kerr J, Liaw C, Oldfield BJ, Tschop MH, Bagnol D	2006-09-26
23979792	Hypothalamic QRFP: regulation of food intake and fat selection. view abstract	Primeaux SD, Barnes MJ, Braymer HD	2013-08-28
25449662	Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae. view abstract	Xu B, Bergqvist CA, Sundstrom G, Lundell I, Vaudry H, Leprince J, Larhammar D	2014-12-03
24532655	Molecular evolution of GPCRs: 26Rfa/GPR103. view abstract	Ukena K, Osugi T, Leprince J, Vaudry H, Tsutsui K	2014-02-18
20534693	GPR103b functions in the peripheral regulation of adipogenesis. view abstract	Mulumba M, Jossart C, Granata R, Gallo D, Escher E, Ghigo E, Servant MJ, Marleau S, Ong H	2010-06-11
16543370	RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. view abstract	Moriya R, Sano H, Umeda T, Ito M, Takahashi Y, Matsuda M, Ishihara A, Kanatani A, Iwaasa H	2006-03-18
26385088	Effects of direct QRFP-26 administration into the medial hypothalamic area on food intake in rats. view abstract	Zagoracz O, Kovacs A, Laszlo K, Ollmann T, Peczely L, Lenard L	2015-09-20
18535111	Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats. view abstract	Patel SR, Murphy KG, Thompson EL, Patterson M, Curtis AE, Ghatei MA, Bloom SR	2008-06-07
16648250	A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. view abstract	Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J	2006-05-02
23964068	QRFP induces aldosterone production via PKC and T-type calcium channel-mediated pathways in human adrenocortical cells: evidence for a novel role of GPR103. view abstract	Ramanjaneya M, Karteris E, Chen J, Rucinski M, Ziolkowska A, Ahmed N, Kagerer S, Johren O, Lehnert H, Malendowicz LK, Randeva HS	2013-08-22

Putative/known Functions

Localisation

Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db Name	Query Uni	Subject Uni	Sequence Length	Alignment Length	Identity	Coverage	Mismatches	Gap Openings	Query Start	Query End	Subject Start	Subject End	Evalue	Bit Score
Reviewed non-human mammalian with experimental evidence	OX26_HUMAN	OX26_RAT	136	119	62.18	87.5	35	3	17	135	16	124	4E-32	132
Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot ID	Interpro ID	Go ID	Type	Name	Category	Description
OX26_HUMAN	IPR024565	GO:0031854	Family	Orexigenic neuropeptide QRFP/P518	Molecular Function	orexigenic neuropeptide QRFP receptor binding
Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR

gpmDB

	Peptide Sequence	Evidence Level	Log E	Number Of Observation	Spectra	Accession ID	Proteotypicity	Annotation
No results found.

Evidence File /mnt/mpp/ms_data/P83859_gpmdb.txt
Reference FenyÃ¶, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056â€“2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM

Peptide Sequence	Evidence Level	Log E	Number Of Observation	Spectra	Accession ID	Proteotypicity
ASQPQALLVIAR	red	-2.4	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.4	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.4	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.4	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.3	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.3	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.2	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.2	12	1	ENSP00000345487	Proteotypic
REPTDAMGGLGAGER	red	-2.1	16	1	ENSP00000345487	Proteotypic
EHAGCRFR	red	-2.1	1	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.1	12	1	ENSP00000345487	Proteotypic
REPTDAMGGLGAGER	red	-2.1	16	1	ENSP00000345487	Proteotypic
EHAGCRFR	red	-2.1	1	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.1	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.0	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.0	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.0	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.0	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.0	12	1	ENSP00000345487	Proteotypic
ASQPQALLVIAR	red	-2.0	12	1	ENSP00000345487	Proteotypic

PRIDE

	Peptide Sequence	Scores	Pride ID	Spectrum ID	Annotation
No results found.

Evidence File /mnt/mpp/ms_data/P83859_pridedb.txt
Reference Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive