Gene Name
Orexigenic neuropeptide QRFP |
Protein ID
P83859 |
Chromosome ID
9 |
HPP Status
2 |
Protein Name
Orexigenic neuropeptide QRFP |
Synonyms
P518 precursor protein RF(Arg-Phe)amide family 26 amino acid peptide (P518) prepro-QRFP "prepro-QRFP" 26RFA pyroglutamylated RFamide peptide P518 26RFa orexigenic neuropeptide QRFP [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ![]() |
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Chromosomal Position
9q34.12 | Start:130892702 End:130892702 |
Sequence
P83859.fasta |
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Description
Entrez Gene Summary for QRFPThe P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including P518. RF-amide peptides share a common C-terminal motif and are involved in cell signaling through G protein-coupled receptors (Jiang et al., 2003 (PubMed 12714592)).(supplied by OMIM, Mar 2008) UniProtKB Summary for QRFPFunction: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity) [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ![]() |
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External IDs
Hgnc ID: 29982 EntrezGene ID: 347148 Ensembl ID: ENSG00000188710 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ![]() |
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Reference Source
http://www.nextprot.org ![]() |
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PubMed ID | GeneRIF Text | Last Update |
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12714592 | P518 exhibited high affinity for SP9155. The peptide P518 precursor gene is predominantly expressed in various brain regions, coronary arteries, thyroid and parathyroid glands, large intestine, colon, bladder, testes, and prostate. | 2010-01-21 |
15808908 | Solution conformation of 26RFa by using two-dimensional NMR spectroscopy in different media was investigated. | 2010-01-21 |
15891009 | A bioinformatic search for peptides related to frog 26RFa reveals the presence of homologous sequences in the human genome. | 2010-01-21 |
16899066 | Characterization of 26RFa-related peptides showed that two distinct molecular forms of 26RFa are present in the human hypothalamus and spinal cord, i.e. 26RFa and an N-terminally elongated form of 43 amino acids designated 43RFa. | 2010-01-21 |
20534693 | Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis. | 2010-11-27 |
22466335 | High levels of circulating 26RFa observed in anorexia nervosa patients might reflect an adaptive mechanism of the organism to promote energy intake and to increase fat stores in response to undernutrition. | 2012-08-18 |
22863147 | Data indicate that 26RFa may participate to the development of prostate cancer at the androgen independent state by promoting the neuroendocrine differentiation and the migration of cancer cells via autocrine/paracrine mechanisms. | 2013-05-11 |
25858563 | we show a moderate positive correlation between plasma 26RFa levels and insulin in patients with diabetes. Plasma 26RFa increases in response to glucose tolerance test. 26RFa and its receptor GPR103 are present in human pancreatic beta-cells and gut. | 2015-10-10 |
Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ![]() ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ |
Db Name | Query Uni | Subject Uni | Sequence Length | Alignment Length | Identity | Coverage | Mismatches | Gap Openings | Query Start | Query End | Subject Start | Subject End | Evalue | Bit Score |
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Reviewed non-human mammalian with experimental evidence | OX26_HUMAN | OX26_RAT | 136 | 119 | 62.18 | 87.5 | 35 | 3 | 17 | 135 | 16 | 124 | 4E-32 | 132 |
Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. |
Uniprot ID | Interpro ID | Go ID | Type | Name | Category | Description |
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OX26_HUMAN | IPR024565 | GO:0031854 | Family | Orexigenic neuropeptide QRFP/P518 | Molecular Function | orexigenic neuropeptide QRFP receptor binding |
Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. |